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Lipidomics of polyunsaturated fatty acid-derived oxygenated metabolites

Nicolaou, Anna
; 
Massey, Karen A.
Publication Date
2011
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Keywords
Lipidomics, Fatty Acids, Mass Spectrometry, Polyunsaturated Fatty Acids, PUFA, Cytochrome P450, Eicosanoid, LOX, COX, Cyclo-Oxygenase, Lipoxygenase
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Abstract
Nutritionally important PUFAs (polyunsaturated fatty acids) mediate some of their bioactivities through formation of oxygenated metabolites. These bioactive lipids are formed by COX (cyclo-oxygenase), LOX (lipoxygenase) and cytochrome-P450-catalysed reactions, as well as non-enzymatic lipid peroxidation. These reactions produce numerous species, some of which can be formed through more than one pathway. MS-based lipidomics offers the selectivity and sensitivity required for qualitative and quantitative analysis of multiple lipid species, in a variety of biological systems, and can facilitate the study of these mediators.
URI
http://hdl.handle.net/10454/5230
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Citation
Massey, K.A. and Nicolaou, A. (2011). Lipidomics of polyunsaturated fatty acid-derived oxygenated metabolites. Biochemical Society Transactions. Vol. 39, No. 5. pp. 1240-1249.
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https://doi.org/10.1042/BST0391240
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