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D1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia

; 
Idris, Nagi F.
; 
Woolley, M.L.
; 
Neill, Joanna C.
Publication Date
2009-06
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Keywords
D1 receptors, Schizophrenia, Recognition memory, Reversal learning, Female rat, Phencyclidine
Rights
© 2009 Elsevier B.V. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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Peer-Reviewed
Yes
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openAccess
Accepted for publication
2009-01-27
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Life Sciences Publications
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McLean_European_Neuropsychopharmacology_2009.pdf
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Abstract
Phencyclidine (PCP) produces cognitive deficits of relevance to schizophrenia in animal models. The aim was to investigate the efficacy of the D1-like receptor agonist, SKF-38393, to improve PCPinduced deficits in the novel object recognition (NOR) and operant reversal learning (RL) tasks. Rats received either sub-chronic PCP (2 mg/kg) or vehicle for 7 days, followed by a 7-day washout. Rats were either tested in NOR or the RL tasks. In NOR, vehicle rats successfully discriminated between novel and familiar objects, an effect abolished in PCP-treated rats. SKF-38393 (6 mg/kg) significantly ameliorated the PCP-induced deficit (Pb0.01) an effect significantly antagonised by SCH-23390 (0.05 mg/kg), a D1-like receptor antagonist (Pb0.01). In the RL task sub-chronic PCP significantly reduced performance in the reversal phase (Pb0.001); SKF-38393 (6.0 mg/kg) improved this PCPinduced deficit, an effect antagonised by SCH-23390 (Pb0.05). These results suggest a role for D1-like receptors in improvement of cognitive function in paradigms of relevance to schizophrenia.
URI
http://hdl.handle.net/10454/8483
Version
Accepted manuscript
Citation
McLean SL, Idris NF, Woolley ML and Neill JC (2009) D1-like receptor activation improves PCP-induced cognitive deficits in animal models: implications for mechanisms of improved cognitive function in schizophrenia. European Neuropsychopharmacology. 19(6): 440-450.
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https://doi.org/10.1016/j.euroneuro.2009.01.009
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Article
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