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HOX transcription factors and the prostate tumor microenvironment
Morgan, Richard Pandha, H.S.
Morgan, Richard
Pandha, H.S.
Publication Date
2017-12
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© The Author(s) 2017. This is an open access article licensed under the terms of Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original author is credited and the new creations are licensed under the identical terms.
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openAccess
Accepted for publication
2017-08-14
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Abstract
It is now well established that the tumor microenvironment plays an essential role in the survival, growth, invasion, and spread of cancer through the regulation of angiogenesis and localized immune responses. This review examines the role of the HOX genes, which encode a family of homeodomain-containing transcription factors, in the interaction between prostate tumors and their microenvironment. Previous studies have established that HOX genes have an important function in prostate cancer cell survival in vitro and in vivo, but there is also evidence that HOX proteins regulate the expression of genes in the cancer cell that influence the tumor microenvironment, and that cells in the microenvironment likewise express HOX genes that confer a tumor-supportive function. Here we provide an overview of these studies that, taken together, indicate that the HOX genes help mediate cross talk between prostate tumors and their microenvironment.
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Citation
Morgan R and Pandha HS (2017) HOX transcription factors and the prostate tumor microenvironment. Journal of Cancer Metastasis and Treatment. 3: 278-287.
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Article