Loading...
mRNA Cap Methylation in Pluripotency and Differentiation
Grasso, L. Suska, O. Davidson, L. Gonatopolous-Pournatzis, T. Williamson, Ritchie Wasmus, L. Wiedlich, S. Peggie, M. Stavridis, M.P. Cowling, V.H.
Grasso, L.
Suska, O.
Davidson, L.
Gonatopolous-Pournatzis, T.
Williamson, Ritchie
Wasmus, L.
Wiedlich, S.
Peggie, M.
Stavridis, M.P.
Cowling, V.H.
Publication Date
2016-08-02
End of Embargo
Supervisor
Rights
(c) 2016 The Authors. This is an Open Access article under the CC-BY
license (http://creativecommons.org/licenses/by/4.0/ )
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Collections
Abstract
The mRNA cap stabilizes transcripts and
recruits processing and translation
factors. Grasso et al. report that the
mRNA cap methyltransferase RNMTRAM
is highly expressed in embryonic
stem cells and is important for
pluripotency-associated gene
expression. Repression of RAM occurs
during neural differentiation and is
important for expression of neuralassociated
genes.
Version
Published version
Citation
Grasso L, Suska O, Davidson L et al (2016) mRNA Cap Methylation in Pluripotency and
Differentiation. Cell Reports. 16: 1-14.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article