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Oxidative DNA damage and repair at non-coding regulatory regions

Publication Date
2023-11
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Keywords
DNA repair, NuMA, Demethylation, Enhancers, Promoters, Transcription
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(c) 2023 The Author. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/)
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openAccess
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Life Sciences Publications
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Abstract
DNA breaks at protein-coding sequences are well-established threats to tissue homeostasis and maintenance. They arise from the exposure to intracellular and environmental genotoxins, causing damage in one or two strands of the DNA. DNA breaks have been also reported in non-coding regulatory regions such as enhancers and promoters. They arise from essential cellular processes required for gene transcription, cell identity and function. One such process that has attracted recent attention is the oxidative demethylation of DNA and histones, which generates abasic sites and DNA single-strand breaks. Here, we discuss how oxidative DNA breaks at non-coding regulatory regions are generated and the recently reported role of NuMA (nuclear mitotic apparatus) protein in promoting transcription and repair at these regions.
URI
http://hdl.handle.net/10454/19673
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Published version
Citation
El-Khamisy SF (2023) Oxidative DNA damage and repair at non-coding regulatory regions. Trends in Cell Biology. 33(11): 939-949.
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https://doi.org/10.1016/j.tcb.2023.03.004
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Article
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