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Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum
Shepherd, J. Chang, Chien-Yi Boyne, J.R. Rimmer, Stephen Martin, William H.C.
Shepherd, J.
Chang, Chien-Yi
Boyne, J.R.
Rimmer, Stephen
Martin, William H.C.
Publication Date
2019-07
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(c) 2019 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license.
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openAccess
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2019-05-29
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Abstract
Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.
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Citation
Shepherd J, Swift T, Chang C-Y, Boyne JR, Rimmer S and Martin WHC (2019) Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum. Chemical Communications. 55(66): 9765-9768.
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Article