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Process simulation of twin-screw granulation: A review

Arthur, Tony B.
; 
Rahmanian, Nejat
Publication Date
2024-06
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Keywords
Twin-screw granulation, Simulation, Discrete element method, Population balance model, Computational fluid dynamics
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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Yes
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openAccess
Accepted for publication
2024-05-21
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Engineering and Digital Technology Publications
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Abstract
Twin-screw granulation has emerged as a key process in powder processing industries and in the pharmaceutical sector to produce granules with controlled properties. This comprehensive review provides an overview of the simulation techniques and approaches that have been employed in the study of twin-screw granulation processes. This review discusses the major aspects of the twin-screw granulation process which include the fundamental principles of twin-screw granulation, equipment design, process parameters, and simulation methodologies. It highlights the importance of operating conditions and formulation designs in powder flow dynamics, mixing behaviour, and particle interactions within the twin-screw granulator for enhancing product quality and process efficiency. Simulation techniques such as the population balance model (PBM), computational fluid dynamics (CFD), the discrete element method (DEM), process modelling software (PMS), and other coupled techniques are critically discussed with a focus on simulating twin-screw granulation processes. This paper examines the challenges and limitations associated with each simulation approach and provides insights into future research directions. Overall, this article serves as a valuable resource for researchers who intend to develop their understanding of twin-screw granulation and provides insights into the various techniques and approaches available for simulating the twin-screw granulation process.
URI
http://hdl.handle.net/10454/19997
Version
Published version
Citation
Arthur TB and Rahmanian N (2024) Process simulation of twin-screw granulation: A review. Pharmaceutics. 16(6): 706.
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Link to published version
Link to Version of Record
https://doi.org/10.3390/pharmaceutics16060706
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Article
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