New polyhydroxy sterols from the marine sponge Callyspongia fibrosa (Ridley and Dendly).
Rao, T.S.P. Sarma, N.S. Murthy, Y.L.N. Kantamreddi, Venkata Siva Satya Narayana Wright, Colin W. Parameswaran, P.S.
Rao, T.S.P.
Sarma, N.S.
Murthy, Y.L.N.
Kantamreddi, Venkata Siva Satya Narayana
Wright, Colin W.
Parameswaran, P.S.
Publication Date
2010
End of Embargo
Supervisor
Rights
Peer-Reviewed
Yes
Open Access status
closedAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
Four new polyhydroxylated sterols are isolated from Marine sponge Callyspongia fibrosa collected from
the Gulf of Mannar, western Bay of Bengal (India). The structural assignment is based on 1H and 13C NMR
spectra. All sterols are based on the known 24S-24-methyl cholesterol 1 which is also isolated, and contain
3b,6b-dihydroxy system and 25-O-acetate as common features (except in the case of sterol 6 that has
a D25 in the place of 25-OAc). Additional OH substitution is also present at 5a in 4a and at 8b in 5. A further
12b-OH is present in 6 and 7. The hydroxylation pattern is so far known only in coral sterols but is
without a precedent in sponge sterols. The major steroid 4a showed antimalarial activity against Plasmodium
falciparum on the chloroquine-resistant stain better than on the chloroquine-sensitive strain.
Version
No full-text in the repository
Citation
Rao, T. S. P., Sarma, N. S., Murthy, Y. L. N., Kantamreddi V. S. S. N., Wright, C. W. and Parameswaran, P. S. (2010). New polyhydroxy sterols from the marine sponge Callyspongia fibrosa (Ridley and Dendly). Tetrahedron Letters, Vol. 51, No. 27, pp. 3583-3586.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article