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Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice
Muha, V. Williamson, Ritchie Hills, R. McNeilly, A.D. McWilliams, T.G. Alonso, J. Schimpl, M. Leney, A.C. Heck, A.J.R. Sutherland, C.
Muha, V.
Williamson, Ritchie
Hills, R.
McNeilly, A.D.
McWilliams, T.G.
Alonso, J.
Schimpl, M.
Leney, A.C.
Heck, A.J.R.
Sutherland, C.
Publication Date
2019-11-06
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© 2019 The Authors.
Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
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openAccess
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2019-11-05
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Abstract
O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain largely unexplored. Here, we show that Ser517 O-GlcNAcylation of the microtubule-binding protein Collapsin Response Mediator Protein-2 (CRMP2) increases with age. By generating and characterizing a Crmp2S517A knock-in mouse model, we demonstrate that loss of O-GlcNAcylation leads to a small decrease in body weight and mild memory impairment, suggesting that Ser517 O-GlcNAcylation has a small but detectable impact on mouse physiology and cognitive function.
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Citation
Muha V, Williamson R, Hills R et al (2019) Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice. Open Biology. 9(11): 190192.
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Article