Prostaglandin D2 production in FM55 melanoma cells is regulated by ¿-melanocyte stimulating hormone and is not related to melanin production.
Masoodi, Mojgan Nicolaou, Anna Gledhill, Karl Rhodes, L.E. Tobin, Desmond J. Thody, Anthony J.
Masoodi, Mojgan
Nicolaou, Anna
Gledhill, Karl
Rhodes, L.E.
Tobin, Desmond J.
Thody, Anthony J.
Publication Date
2010
End of Embargo
Supervisor
Rights
Peer-Reviewed
Yes
Open Access status
closedAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. ¿-Melanocyte stimulating hormone (¿-MSH), which had no effect on melanin production in FM55 cells, stimulated PGD2 production in these cells without affecting PGE2. While cAMP pathways may be involved in regulating PGD2 production, our results suggest that ¿-MSH acts independently of cAMP, possibly by regulating the activity of lipocalin-type PGD synthase. This ¿-MSH-mediated effect may be associated with its role as an immune modulator.
Version
No full-text in the repository
Citation
Masoodi, M., Nicolaou, A., Gledhill, K., Rhodes, L. E., Tobin, D. J. and Thody, A. J. (2010). Prostaglandin D2 production in FM55 melanoma cells is regulated by ¿-melanocyte-stimulating hormone and is not related to melanin production. Experimental Dermatology, Vol. 19, No. 8, pp. 751¿753.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article