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Membrane-type matrix metalloproteinases: expression, roles in metastatic prostate cancer progression and opportunities for drug targeting
Falconer, Robert A.
Falconer, Robert A.
Publication Date
2017-12
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© The Author(s) 2017. This is an open access article licensed under the terms of Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original author is credited and the new creations are licensed under the identical terms.
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Open Access status
openAccess
Accepted for publication
2017-10-26
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Abstract
The membrane-type matrix metalloproteinases (MT-MMPs), an important subgroup of
the wider MMP family, demonstrate widespread expression in multiple tumor types, and
play key roles in cancer growth, migration, invasion and metastasis. Despite a large body
of published research, relatively little information exists regarding evidence for MT-MMP
expression and function in metastatic prostate cancer. This review provides an appraisal of
the literature describing gene and protein expression in prostate cancer cells and clinical
tissue, summarises the evidence for roles in prostate cancer progression, and examines
the data relating to MT-MMP function in the development of bone metastases. Finally, the
therapeutic potential of targeting MT-MMPs is considered. While MT-MMP inhibition
presents a significant challenge, utilisation of MT-MMP expression and proteolytic capacity
in prostate tumors is an attractive drug development opportunity.
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Published version
Citation
Falconer RA and Loadman PM (2017) Membrane-type matrix metalloproteinases: expression, roles in metastatic prostate cancer progression and opportunities for drug targeting. Journal of Cancer Metastasis and Treatment. 3: 315-327.
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Article