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Identifying and targeting the molecular signature of smooth muscle cells undergoing early vascular ageing
Richces-Suman, Kirsten Hussain, Alisah
Richces-Suman, Kirsten
Hussain, Alisah
Publication Date
2022-07-01
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(c) 2022 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/)
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2022-03-25
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Abstract
Early vascular ageing (EVA) is a pathological phenomenon whereby the vascular system ages more quickly than chronological age. This underpins many cardiovascular diseases including the complications of type 2 diabetes, aneurysm formation and hypertension. Smooth muscle cells (SMC) are the principal cell type in the vascular wall and maintain vascular tone. EVA-related phenotypic switching of these cells contributes towards disease progression. EVA is distinct from chronological ageing, and research is ongoing to identify a definitive molecular signature of EVA. This will facilitate the discovery of new clinical tests for early detection of EVA and identify therapeutic targets to halt (or prevent) EVA in SMC, thus reducing macrovascular morbidity and mortality.
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Citation
Riches-Suman K and Hussain A (2022) Identifying and targeting the molecular signature of smooth muscle cells undergoing early vascular ageing. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1868(7): 166403.
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Article