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Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol–ene radical reactions
Sun, L. Pitto-Barry, Anaïs Thomas, A.W. Inam, M. Doncom, K.E.B. Dove, A.P. O'Reilly, R.K.
Sun, L.
Pitto-Barry, Anaïs
Thomas, A.W.
Inam, M.
Doncom, K.E.B.
Dove, A.P.
O'Reilly, R.K.
Publication Date
2016-04-07
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© 2016 RSC. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
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2016-02-12
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Abstract
Sequential ring-opening and reversible addition–fragmentation chain transfer (RAFT) polymerization was used to form a triblock copolymer of tetrahydropyran acrylate (THPA), 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC) and L-lactide. Concurrent deprotection of the THPA block and crystallization-driven self-assembly (CDSA) was undertaken and allowed for the formation of cylindrical micelles bearing allyl handles in a short outer core segment. These handles were further functionalized by different thiols using photo-initiated thiol–ene radical reactions to demonstrate that the incorporation of an amorphous PMAC block within the core does not disrupt CDSA and can be used to load the cylindrical nanoparticles with cargo.
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Sun L, Pitto-Barry A, Thomas AW, Inam M, Dove AP and O'Reilly RK (2016) Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol–ene radical reactions. Polymer Chemistry. 7(13): 2337-2341.
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Article