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Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv.

Stavri, M.
; 
Matthew, K.T.
; 
Gordon, Andrew
; ; 
Falconer, Robert A.
; 
Gibbons, S.
Publication Date
2008-03-17
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Keywords
Sesquiterpene, Guaianolide, Pulicaria Crispa, Mycobacterium, Pseudoguaianolide
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Abstract
A phytochemical study of the asteraceous herb Pulicaria crispa (Forssk.) Oliv. resulted in the characterisation of three guaianolide sesquiterpenes, 2α,4α-dihydroxy-7αH,8αH,10αH-guaia-1(5),11(13)-dien-8β,12-olide (1), 1α,2α-epoxy-4β-hydroxy-5αH,7αH,8αH,10αH-guaia-11(13)-en-8β,12-olide (2) and 5,10-epi-2,3-dihydroaromatin (3). The structures were assigned on the basis of extensive 1 and 2D NMR experiments. Compound 3 exhibited weak antimycobacterial activity against Mycobacterium phlei with a minimum inhibitory concentration of 0.52 mM and cytotoxicity (IC50 of 5.8 ± 0.2 μM) in a human bladder carcinoma cell line, EJ-138.
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http://hdl.handle.net/10454/4618
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Citation
Stavri M, Matthew KT, Gordon A et al (2008) Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv.. Phytochemistry. 69(9): 1915-1918.
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https://doi.org/10.1016/j.phytochem.2008.03.012
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