Loading...
Construction of Ternary Phase Diagrams: Application of Quantitative NMR
Telford, Richard Obule, Whitney Seaton, Colin C.
Telford, Richard
Obule, Whitney
Seaton, Colin C.
Publication Date
2022-02
End of Embargo
Supervisor
Rights
© 2022 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.1c01311
Peer-Reviewed
Yes
Open Access status
embargoedAccess
Accepted for publication
2021-11-09
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
The growth of cocrystalline phases continues to expand as a key area of crystal engineering research. Understanding the phase behavior of the material and controlling the crystalline form of the material from a solution-based route can be aided by the construction of a ternary phase diagram for the system. A range of methods exist for this process which display a variety of costs and time to achieve the final diagram. The application of quantitative NMR (qNMR) to this problem offers a fast analysis method to directly determine the solution composition of all species (coformers and solvent) and is demonstrated to successfully allow the construction of ternary diagrams with and without a cocrystal phase being formed for systems with high and low solubility.
Version
Accepted manuscript
Citation
Telford R, Obule W and Seaton CC (2022) Construction of Ternary Phase Diagrams: Application of Quantitative NMR. Crystal Growth and Design. 22(3): 1724-1730.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article