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Gene Regulation at a Distance: Higher-Order Chromatin Folding and the Coordinated Control of Gene Transcription at the Epidermal Differentiation Complex Locus

Fessing, Michael Y.
Publication Date
2014
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Keywords
Gene regulation, Higher-order chromatin folding, Gene transcription, Gene regulatory elements, Epidermis, Epidermal Differentiation Complex Locus
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closedAccess
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Life Sciences Publications
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Abstract
Chromatin structure and spatial interactions between proximal and distal gene regulatory elements, including gene core promoters and enhancers, are important in the control of gene transcription. In this issue, Oh et al. characterized an AP-1-dependent enhancer at the epidermal differentiation complex locus that establishes spatial interactions with numerous gene promoter regions at that locus.
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http://hdl.handle.net/10454/6831
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Citation
Fessing, M. Y. (2014) Gene regulation at a distance: higher-order chromatin folding and the coordinated control of gene transcription at the epidermal differentiation complex locus. Journal of Investigative Dermatology, 134 (9) 2307-10
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https://doi.org/10.1038/jid.2014.247
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