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Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol plus Water Mixtures at 298.2 K

Ali, Hany S.M.
; 
York, Peter
; 
Blagden, Nicholas
; 
Soltanpour, S.
; 
Acree, W.E. Jr.
; 
Jouyban, A.
Publication Date
2010-01
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Keywords
Solubility, Crystal engineering, Budesonide, Hydrocortisone, Prednisolone, Ethanol and water mixtures
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Abstract
Experimental solubilities of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2 K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum values of the volume fractions of 90 %, 80 %, and 80 % of ethanol. The Jouyban-Acree model was used to fit the experimental data, and the solubilities were reproduced using previously trained versions of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 5.1 %, 6.4 %, 37.7 %, and 35.9 %, respectively, for the fitted model, the trained version for ethanol + water mixtures, and generally trained versions for various organic solvents + water mixtures. Solubilities were also predicted by a previously established log-linear model of Yalkowsky with the OMRD of 53.8 %.
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http://hdl.handle.net/10454/4853
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Citation
Ali, H.S.M., York, P., Blagden, P., Soltanpour, S., Acree, Jr., W.E. and Jouyban, A. (2010). Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol plus Water Mixtures at 298.2 K. Journal of Chemical and Engineering Data. Vol. 55, No. 1, pp. 578-582.
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https://doi.org/10.1021/je900376r
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