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Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish

Kim, H.R.
; 
Santhakumar, K.
; 
Markham, E.
; 
Baldera, D.
; 
Greenald, D.
; 
Bryant, H.E.
; ; 
van Eeden, F.J.
Publication Date
2020-03
End of Embargo
Supervisor
Keywords
Hif, Vhl, DNA repair, Apoptosis, Chemo/radio-resistance
Rights
Copyright: Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Yes
Open Access status
openAccess
Accepted for publication
2020-02-17
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Life Sciences Publications
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Abstract
pVHL is a tumor suppressor. The lack of its function leads to various tumors, among which ccRCC (clear cell renal cell carcinoma) has the most serious outcome due to its resistance to chemotherapies and radiotherapies. Although HIF promotes the progression of ccRCC, the precise mechanism by which the loss of VHL leads to tumor initiation remains unclear. We exploited two zebrafish vhl mutants, vhl and vll, and Tg(phd3
URI
http://hdl.handle.net/10454/18019
Version
Published version
Citation
Kim HR, Santhakumar K, Markham E et al (2020) Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish. Oncotarget. 11(13): 1109-1130.
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Link to Version of Record
https://doi.org/10.18632/oncotarget.27521
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Article
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