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Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field
McLean, Samantha Woolley, M.L. Neill, Joanna C.
McLean, Samantha
Woolley, M.L.
Neill, Joanna C.
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Publication Date
2010-05
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The final, definitive version of this paper has been published in Journal of Psychopharmacology, vol 24/issue 5 by SAGE Publications Ltd, All rights reserved. © 2010 SAGE Publications Ltd.
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Abstract
Female hooded-Lister rats received either sub-chronic phencyclidine (PCP) (2 mg/kg, n=20) or vehicle (1 ml/kg, n=20) i.p. twice daily for seven days, followed by a seven-day washout period. Rats were challenged with acute PCP or vehicle and tested for locomotor activity to ensure hyperactivity was observed in the sub-chronic PCP treated rats. Rats were then tested on the elevated plus maze and in an open field for 10 minutes. Sub-chronic PCP did not significantly affect behaviour on the elevated plus maze or in the open field. In conclusion, sub-chronic PCP does not induce anxiety-like behaviour.
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McLean SL, Woolley ML and Neill JC (2010) Effects of sub-chronic phencyclidine on behaviour of female rats on the elevated plus maze and open field. Journal of Psychopharmacology. 24(5): 787-790.
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