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A simple method for estimating in vitro air-tissue and in vivo blood-tissue partition coefficients
Abraham, M.H. Gola, J.M.R. Ibrahim, A. Acree, W.E. Jr. Liu, Xiangli
Abraham, M.H.
Gola, J.M.R.
Ibrahim, A.
Acree, W.E. Jr.
Liu, Xiangli
Publication Date
2015-02
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© 2014. Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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Yes
Open Access status
openAccess
Accepted for publication
2014-06-14
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Abstract
A simple method is reported for the estimation of in vivo air-tissue partition coefficients of VOCs and of in vitro blood-tissue partition coefficients for volatile organic compounds and other compounds. Linear free energy relationships for tissues such as brain, muscle, liver, lung, kidney, heart, skin and fat are available and once the Abraham descriptors are known for a compound, no more than simple arithmetic is required to estimate air-tissue and blood-tissue partitions.
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Accepted manuscript
Citation
Abraham MH, Gola JMR, Ibrahim A et al. (2015) A simple method for estimating in vitro
air-tissue and in vivo blood-tissue partition coefficients. Chemosphere. 120: 188-191.
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Article