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Nanoparticles of chitosan conjugated to organo-ruthenium complexes
Wang, Y. Pitto-Barry, Anaïs Habtemariam, A. Romero-Canelón, I. Sadler, P.J. Barry, Nicolas P.E.
Wang, Y.
Pitto-Barry, Anaïs
Habtemariam, A.
Romero-Canelón, I.
Sadler, P.J.
Barry, Nicolas P.E.
Publication Date
2016
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© 2016 The Royal Society of Chemistry. Reproduced in accordance with
the publisher's self-archiving policy. This article is licensed under a Creative Commons
Attribution 3.0 Unported Licence.
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openAccess
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2016-06-11
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Abstract
The synthesis of nanoparticles of conjugates of caffeic acid-modified chitosan with ruthenium arene
complexes is described. The chemical structure and physical properties of the nanoparticles were characterised
by electronic absorption spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR),
1H NMR spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray
powder diffraction (XRD), and circular dichroism (CD) analysis. The multi-spectral results revealed that
caffeic acid is covalently bound to chitosan and chelates to {Ru(p-cymene)Cl}+. The DLS studies indicated
that the Ru–caffeic acid modified chitosan nanoparticles are well-defined and of nanometre size. Such
well-defined nanocomposites of chitosan and metal complexes might find a range of applications, for
example in drug delivery.
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Citation
Wang Y, Pitto-Barry A, Habtemariam A et al (2016) Nanoparticles of chitosan conjugated
to organo-ruthenium complexes. Inorganic Chemistry Frontiers. 3(8): 1058-1064.
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