Preclinical studies of saponons for tumor therapy
Bachran, C. Bachran, S. Bachran, D. Fuchs, H.
Bachran, C.
Bachran, S.
Bachran, D.
Fuchs, H.
Publication Date
2014
End of Embargo
Supervisor
Rights
Peer-Reviewed
Yes
Open Access status
closedAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Collections
Abstract
Various saponins, plant glycosides with favorable anti-tumorigenic properties, have been used to inhibit tumor cell growth by cell cycle arrest and apoptosis with IC50 values of up to 0.2 μM. We describe several groups of saponins (dioscins, saikosaponins, julibrosides, soy saponins, ginseng saponins and avicins) currently investigated for their use in tumor therapy. We focus on cellular and systemic mechanisms of tumor cell growth inhibition both in vitro and in vivo, combinational approaches with saponins and conventional tumor treatment strategies, and successful syntheses of saponins. The increasing interest in saponins for tumor therapy is very promising for the future development of sophisticated anti-cancer drugs.
Version
No full-text in the repository
Citation
Bachran C, Bachran S, Sutherland M et al (2014) Preclinical studies of saponons for tumor therapy. In: Atta-Ur-Rahman and Perry G (Eds) Recent Advances in Medicinal Chemistry. Vol. 1. Bentham Books: Oxford, UK: 272-302.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Book chapter