Loading...
Continuous multi-step synthesis by extrusion - telescoping solvent-free reactions for greater efficiency
Crawford, Deborah E. Miskimmin, C.K. Cahir, J. James, S.L.
Crawford, Deborah E.
Miskimmin, C.K.
Cahir, J.
James, S.L.
Publication Date
2017-11
End of Embargo
Supervisor
Rights
© The Royal Society of Chemistry 2017. This work is made available online in accordance with the publisher's policies. Please refer to any applicable terms of use of the publisher.
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2017-11-10
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
Chemical manufacturing typically requires more than one step,
involving multiple batch processes, which makes synthesis at scale
laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be
carried out as a continuous multi-component reaction (MCR), by
twin screw extrusion (TSE), in the complete absence of solvent.
Version
Accepted manuscript
Citation
Crawford DE, Miskimmin CK, Cahir J et al (2017) Continuous multi-step synthesis by extrusion - telescoping solvent-free reactions for greater efficiency. Chemical Communications. 53(97): 13067-13070.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article