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Comparative analysis of granule properties in continuous granulators
Sekyi, Nana Kelly, Adrian L.
Sekyi, Nana
Kelly, Adrian L.
Publication Date
2023-07
End of Embargo
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Rights
© 2023 The Authors. Published by Elsevier B.V. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
(http://creativecommons.org/licenses/by-nc-nd/4.0/).
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2023-04-12
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Abstract
Several contributions in answering granulation challenges including the use of computer simulation and well thought out experimental analyses are being researched. Using a twin screw granulator (TSG) by design of experiments (DoE), comparisons on 1) equipment similarities i.e., continuous and 2) shear forces, are made to previous literature on continuous equipment and a Cyclomix. This study proposes that equipment specific DoE, better explains the contribution of parameters than investigating an identified parameter from the experimental findings from a specific equipment. Granule strength and structure are presented together with the contribution of process parameters, speed, temperature, and binder content. Seeded structures are present in all but the Extrudomix. Longer residence times within the Cyclomix facilitates seeded structures. Granule crushing strengths are higher in TSG than all other continuous equipment. Optimum condition for the formation of stronger granules with least variation is around 65.4 °C.
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Published version
Citation
Sekyi N, Kelly A and Rahmanian N (2023) Comparative analysis of granule properties in continuous granulators. Powder Technology. 425: 118557.
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Article