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Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow
Beggs, Clive B. Magnano, C.R. Shepherd, Simon J. Marr, K. Valnarov, V. Hojnacki, D. Bergsland, N. Belov, P. Grisafi, S. Dwyer, Michael G.
Beggs, Clive B.
Magnano, C.R.
Shepherd, Simon J.
Marr, K.
Valnarov, V.
Hojnacki, D.
Bergsland, N.
Belov, P.
Grisafi, S.
Dwyer, Michael G.
Publication Date
2014-10
End of Embargo
Supervisor
Rights
© 2014 Wiley. This is the peer reviewed version of the following article: Beggs, C. B., Magnano, C., Shepherd, S. J., Marr, K., Valnarov, V., Hojnacki, D., Bergsland, N., Belov, P., Grisafi, S., Dwyer, M. G., Carl, E., Weinstock-Guttman, B. and Zivadinov, R. (2014) Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow. Journal of Magnetic Resonance Imaging. 40: 1215–1222, which has been published in final form at http://dx.doi.org/10.1002/jmri.24468. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Peer-Reviewed
yes
Open Access status
Accepted for publication
2013-09-15
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Awarded
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Abstract
To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius (AoS) in chronic cerebrospinal venous insufficiency (CCSVI)-positive and -negative healthy individuals using cine phase contrast imaging.
Materials and Methods
Fifty-one healthy individuals (32 CCSVI-negative and 19 age-matched CCSVI-positive subjects) were examined using Doppler sonography (DS). Diagnosis of CCSVI was established if subjects fulfilled ≥2 venous hemodynamic criteria on DS. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and routine 3T MRI outcomes.
Results
CCSVI was associated with increased CSF pulsatility in the AoS. Net positive CSF flow was 32% greater in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.008). This was accompanied by a 28% increase in the mean aqueductal characteristic signal (ie, the AoS cross-sectional area over the cardiac cycle) in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.021).
Conclusion
CSF dynamics are altered in CCSVI-positive healthy individuals, as demonstrated by increased pulsatility. This is accompanied by enlargement of the AoS, suggesting that structural changes may be occurring in the brain parenchyma of CCSVI-positive healthy individuals
Version
Accepted Manuscript
Citation
Beggs, C. B., Magnano, C., Shepherd, S. J., Marr, K., Valnarov, V., Hojnacki, D., Bergsland, N., Belov, P., Grisafi, S., Dwyer, M. G., Carl, E., Weinstock-Guttman, B. and Zivadinov, R. (2014) Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow. Journal of Magnetic Resonance Imaging. 40: 1215–1222.
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Article