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Associations of autozygosity with a broad range of human phenotypes
Clark, D.W. Okada, Y. Moore, K.H.S. Mason, D. Pirastu, N. Gandin, I. Mattsson, H. Barnes, C.L.K. Lin, K. Zhao, J.H.
Clark, D.W.
Okada, Y.
Moore, K.H.S.
Mason, D.
Pirastu, N.
Gandin, I.
Mattsson, H.
Barnes, C.L.K.
Lin, K.
Zhao, J.H.
Publication Date
2019-10
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Ā© 2019, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License.
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2019-08-30
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Abstract
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (pā<ā0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44ā66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
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Clark DW, Okada Y, Moore KHS, et al. (2019) Associations of autozygosity with a broad range of human phenotypes. Nature Communications. 10(1): 4957
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