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Core (Polystyrene)−Shell [Poly(glycerol monomethacrylate)] Particles
Mckenzie, A. Hoskins, Richard Grant, Colin A. Rimmer, Stephen
Mckenzie, A.
Hoskins, Richard
Grant, Colin A.
Rimmer, Stephen
Publication Date
2017
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(c) 2017 ACS. This is an Open Access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2017-02-13
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Abstract
A set of water-swollen core−shell particles was
synthesized by emulsion polymerization of a 1,3-dioxolane
functional monomer in water. After removal of the 1,3-
dioxolane group, the particles’ shells were shown to swell in
aqueous media. Upon hydrolysis, the particles increased in size
from around 70 to 100−130 nm. A bicinchoninic acid assay
and ζ-potential measurements were used to investigate the
adsorption of lysozyme, albumin, or fibrinogen. Each of the
core−shell particles adsorbed significantly less protein than the
noncoated core (polystyrene) particles. Differences were
observed as both the amount of difunctional, cross-linking
monomer and the amount of shell monomer in the feed were changed. The core−shell particles were shown to be resistant to
protein adsorption, and the degree to which the three proteins adsorbed was dependent on the formulation of the shell.
Version
Published version
Citation
Mckenzie A, Hoskins R, Swift T et al (2017) Core (Polystyrene)−Shell [Poly(glycerol monomethacrylate)] Particles. ACS Applied Materials and Interfaces. 9(8): 7577-7590.
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Article