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Truncated azinomycin analogues intercalate into DNA.

Casely-Hayford, M.A.
; ; 
Patterson, Laurence H.
; 
Gerner, C.
; 
Neidle, S.
; 
Searcey, M.
Publication Date
2005
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Keywords
Azinomycin, Intercalation, DNA unwinding, Synthesis, Analogues
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Abstract
The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding. Graphical abstract A designed analogue of the left half of azinomycin has been synthesized and unwinds supercoiled DNA.
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https://bradscholars.brad.ac.uk/handle/10454/3908.2
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Citation
Casely-Hayward, M., Pors, K., Patterson, L.H. and Gerner, C. et al. (2005). Truncated azinomycin analogues intercalate into DNA. Bioorganic Medicinal Chemistry Letters. Vol. 15, No. 3, pp. 653-656.
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https://doi.org/10.1016/j.bmcl.2004.11.037
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