Advances in computational modeling and simulation of wet granulation processes
Arthur, Tony B.
Arthur, Tony B.
Publication Date
2025
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Abstract
Granulation is an essential procedure in various industries, particularly in the pharmaceutical sector, as it is needed for producing solid forms of drugs. The complex interaction of process factors, equipment design, and material qualities has led to an increasing use of computer modeling and simulation tools to understand, improve, and control granulation operations. This literature study offers a comprehensive examination of the latest improvements in modeling approaches employed for simulating different types of wet granulators. The work highlights significant advancements in the application of the discrete element method (DEM) for gaining insights into particle-level interactions, mixing, and granule formation. The book examines the incorporation of DEM and the population balance model in the simulation of wet granulation. Furthermore, the work investigates the integration of DEM with computational fluid dynamics and experimental characterization techniques to develop multiscale models that accurately depict the interplay between fluid dynamics and particle behavior in granulation processes.
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Rahmanian N and Arthur TB (2025) Advances in computational modeling and simulation of wet granulation processes. In: Narang AS and Badawy SIF (Eds) Handbook of Pharmaceutical Wet Granulation. 2nd edition. San Diego: Academic Press. Pp. 747-800.
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