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Caenorhabditis elegans in microgravity: An omics perspective
Scott, A. Willis, Craig R.G. Muratani, M. Higashitani, A. Etheridge, T. Szewczyk, N.J. Deane, C.S.
Scott, A.
Willis, Craig R.G.
Muratani, M.
Higashitani, A.
Etheridge, T.
Szewczyk, N.J.
Deane, C.S.
Publication Date
2023-07
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© 2023 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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Yes
Open Access status
openAccess
Accepted for publication
2023
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Abstract
The application of omics to study Caenorhabditis elegans (C. elegans) in the context of spaceflight is increasing, illuminating the wide-ranging biological impacts of spaceflight on physiology. In this review, we highlight the application of omics, including transcriptomics, genomics, proteomics, multi-omics, and integrated omics in the study of spaceflown C. elegans, and discuss the impact, use, and future direction of this branch of research. We highlight the variety of molecular alterations that occur in response to spaceflight, most notably changes in metabolic and neuromuscular gene regulation. These transcriptional features are reproducible and evident across many spaceflown species (e.g., mice and astronauts), supporting the use of C. elegans as a model organism to study spaceflight physiology with translational capital. Integrating tissue-specific, spatial, and multi-omics approaches, which quantitatively link molecular responses to phenotypic adaptations, will facilitate the identification of candidate regulatory molecules for therapeutic intervention and thus represents the next frontiers in C. elegans space omics research.
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Published version
Citation
Scott A, Willis CRG, Muratani M et al (2023) Caenorhabditis elegans in microgravity: An omics perspective. iScience. 26(7): 107189.
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Article