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Structural Motifs in Salts of Sulfathiazole: Implications for Design of Salt Forms in Pharmaceuticals APIs
Seaton, Colin C. Rayan, R.T. Essifaow, E.A.A. Nauha, E. Munshi, Tasnim Scowen, Ian J.
Seaton, Colin C.
Rayan, R.T.
Essifaow, E.A.A.
Nauha, E.
Munshi, Tasnim
Scowen, Ian J.
Publication Date
2018
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(c) 2018 Royal Society of Chemistry. Full-text reproduced in accordance with the publisher's self-archiving policy.
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openAccess
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2018-05-29
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Abstract
The creation of salts is a frequently used approach for the modification of physicochemical properties of an active pharmaceutical ingredient. Despite the frequency of application, there has been little research into the structural-property relationships of the final material and the nature of the counterion present. This work reports on five new salts of sulfathiazole and compares the energetics of the intermolecular interactions with variation in the crystal packing motifs.
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Accepted manuscript
Citation
Seaton CC, Thomas RR, Essfaow EAA et al (2018) Structural Motifs in Salts of Sulfathiazole: Implications for Design of Salt Forms in Pharmaceuticals APIs. CrystEngComm. 20(24): 3428-3434.
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Article