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Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel
Al-Mosawi, M. Davis, G.R. Bushby, A. Montgomery, J. Beaumont, Julia Al-Jawad, M.
Al-Mosawi, M.
Davis, G.R.
Bushby, A.
Montgomery, J.
Beaumont, Julia
Al-Jawad, M.
Publication Date
2018-09
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© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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openAccess
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2018-08-30
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Abstract
For dental human enamel, what is the precise mineralization progression spatially and the precise timings of mineralization?
This is an important question in the fundamental understanding of matrix-mediated biomineralization events, but in particular
because we can use our understanding of this natural tissue growth in humans to develop biomimetic approaches to repair and
replace lost enamel tissue. It is important to understand human tissues in particular since different species have quite distinct
spatial and temporal progression of mineralization. In this study, five human central incisors at different stages of enamel
maturation/mineralization were spatially mapped using synchrotron X-ray diffraction and X-ray microtomography techniques.
From the earliest developmental stage, two crystallite-orientation populations coexist with angular separations between the
crystallite populations averaging approximately 40o and varying as a function of position with the tooth crown. In general,
population one had significantly lower texture magnitude and contributed a higher percentage to the overall crystalline structure,
compared to population two which only contributed 20-30% but had significantly higher texture magnitude. This quantitative
analysis allows us to understand the complex and co-operative structure-function relationship between two populations of
crystallites within human enamel. There was an increase in the mineral concentration from the enamel-dentin junction
peripherally and from the incisal tip cervically as a function of maturation time. Quantitative backscattered-electron analyses
revealed that mineralization of prism cores precedes that of prism boundaries. These results provide new insights into the
precise understanding of the natural growth of human enamel.
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Published version
Citation
Al-Mosawi M, Davis GR, Bushby A et al (2018) Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel. Scientific Reports. 8: 14449.
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Article