Fas signaling is involved in the control of hair follicle response to chemotherapy.
Sharov, A.A. Siebenhaar, F. Sharova, T.Y. Botchkareva, Natalia V. Gilchrest, B.A. Botchkarev, Vladimir A.
Sharov, A.A.
Siebenhaar, F.
Sharova, T.Y.
Botchkareva, Natalia V.
Gilchrest, B.A.
Botchkarev, Vladimir A.
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2004
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Abstract
Chemotherapeutic agents induce p53-dependent apoptosis in the hair follicle (HF) resulting in hair loss, a common side effect of cancer therapy. Here, we show that Fas as a p53 target plays important role in the HF response to cyclophosphamide. Specifically, we demonstrate that Fas is up-regulated in HF keratinocytes after cyclophosphamide treatment, Fas ligand-neutralizing antibody partially inhibits HF response to cyclophosphamide in wild-type mice, and Fas knockout mice show significant retardation of cyclophosphamide-induced HF involution associated with reduced Fas-associated death domain and caspase-8 expression. These data raise a possibility to explore blockade of Fas signaling as a part of complex local therapy for inhibiting keratinocyte apoptosis and hair loss induced by chemotherapy.
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Sharov, A.A., Siebenhaar, F., Sharova, T.Y., Botchkareva, N.V. and Gilchrist, B.A.(2004). Fas signaling is involved in the control of hair follicle response to chemotherapy. Cancer Research. Vol. 64, No. 17, pp. 6266-6270.
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