Fas signaling is involved in the control of hair follicle response to chemotherapy.
Sharov, A.A. ; Siebenhaar, F. ; Sharova, T.Y. ; Botchkareva, Natalia V. ; Gilchrest, B.A. ; Botchkarev, Vladimir A.
Sharov, A.A.
Siebenhaar, F.
Sharova, T.Y.
Botchkareva, Natalia V.
Gilchrest, B.A.
Botchkarev, Vladimir A.
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2004
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Abstract
Chemotherapeutic agents induce p53-dependent apoptosis in the hair follicle (HF) resulting in hair loss, a common side effect of cancer therapy. Here, we show that Fas as a p53 target plays important role in the HF response to cyclophosphamide. Specifically, we demonstrate that Fas is up-regulated in HF keratinocytes after cyclophosphamide treatment, Fas ligand-neutralizing antibody partially inhibits HF response to cyclophosphamide in wild-type mice, and Fas knockout mice show significant retardation of cyclophosphamide-induced HF involution associated with reduced Fas-associated death domain and caspase-8 expression. These data raise a possibility to explore blockade of Fas signaling as a part of complex local therapy for inhibiting keratinocyte apoptosis and hair loss induced by chemotherapy.
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Sharov, A.A., Siebenhaar, F., Sharova, T.Y., Botchkareva, N.V. and Gilchrist, B.A.(2004). Fas signaling is involved in the control of hair follicle response to chemotherapy. Cancer Research. Vol. 64, No. 17, pp. 6266-6270.
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