Dynamic Peptide Library for the Discovery of Charge Transfer Hydrogels
Berdugo, C. Nalluri, S.K.M. Javid, Nadeem Escuder, B. Miravet, J.F. Ulijn, R.V.
Berdugo, C.
Nalluri, S.K.M.
Javid, Nadeem
Escuder, B.
Miravet, J.F.
Ulijn, R.V.
Publication Date
25/11/2015
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05/11/2015
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Abstract
Coupling of peptide self-assembly to dynamic sequence exchange provides a useful approach for the discovery of self-assembling materials. In here, we demonstrate the discovery and optimization of aqueous, gel-phase nanostructures based on dynamically exchanging peptide sequences that self-select to maximize charge transfer of n-type semiconducting naphthalenediimide (NDI)-dipeptide bioconjugates with various π-electron-rich donors (dialkoxy/hydroxy/amino-naphthalene or pyrene derivatives). These gel-phase peptide libraries are characterized by spectroscopy (UV–vis and fluorescence), microscopy (TEM), HPLC, and oscillatory rheology and it is found that, of the various peptide sequences explored (tyrosine Y-NDI with tyrosine Y, phenylalanine F, leucine L, valine V, alanine A or glycine G-NH2), the optimum sequence is tyrosine-phenylalanine in each case; however, both its absolute and relative yield amplification is dictated by the properties of the donor component, indicating cooperativity of peptide sequence and donor/acceptor pairs in assembly. The methodology provides an in situ discovery tool for nanostructures that enable dynamic interfacing of supramolecular electronics with aqueous (biological) systems.
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Berdugo C, Nalluri SKM, Javid N et al (2015) Dynamic Peptide Library for the Discovery of Charge Transfer Hydrogels. ACS Applied Materials and Interfaces. 7(46): 25946-25954.
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