Antiplasmodial compounds from Cassia siamea stem bark extract.
Ajaiyeoba, E.O. Ashidi, J.S. Okpako, Larry Commander Houghton, P.J. Wright, Colin W.
Ajaiyeoba, E.O.
Ashidi, J.S.
Okpako, Larry Commander
Houghton, P.J.
Wright, Colin W.
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2008
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Abstract
Cassia siamea L. (Fabaceae) was identified from the southwest Nigerian ethnobotany as a remedy for febrile illness. This led to the bioassay-guided fractionation of stem bark of the plant extract, using the parasite lactate dehydrogenase assay and multi-resistant strain of Plasmodium falciparum (K1) for assessing the in vitro antimalarial activity. Emodin and lupeol were isolated from the ethyl acetate fraction by a combination of chromatographic techniques. The structures of the compounds were determined by spectroscopy, co-spotting with authentic samples and comparison with literature data. Both compounds were found to be the active principles responsible for the antiplasmodial property with IC50 values of 5 µg/mL, respectively.
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Ajaiyeoba, E. O., Ashidi, J. S., Okpako, L. C., Houghton, P. J. and Wright, C. W. (2008). Antiplasmodial compounds from Cassia siamea stem bark extract. Phytotherapy Research. Vol. 22, pp. 254¿255. doi: 10.1002/ptr.2254.
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