Prostaglandin production by melanocytic cells and the effect of a-melanocyte stimulating hormone
Nicolaou, Anna Estdale, Siân E. Tsatmali, Marina Herrero, Daniel Pascual Thody, Anthony J.
Nicolaou, Anna
Estdale, Siân E.
Tsatmali, Marina
Herrero, Daniel Pascual
Thody, Anthony J.
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2004
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Abstract
Prostaglandins are potent mediators of the inflam-matory response and are also involved in cancer development. In this study, we show that human melanocytes and FM55 melanoma cells express cyclooxygenase-1 and -2 (COX-1 and-2) and thus have the capability to produce prostaglandins. TheFM55 cells produced predominantly PGE2and PGF2a, whereas the HaCaT keratinocyte cell line produced mainly PGE2. The anti-inflammatory peptide, a-melanocyte stimulating hormone(a-MSH), reduced prostaglandin production in FM55 and HaCaT cells and reversed the effect of the pro-inflammatory cytokine TNF-a in the former. These results indicate that melanocytes produce prostaglandins and that a-MSH, by inhibiting this response, may play an important role in regulating inflammatory responses in the skin.
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Nicolaou A, Estdale SE, Tsatmali M, Herrero DP and Thody AJ (2004). Prostaglandin production by melanocytic cells and the effect of melanocyte stimulating hormone. FEBS Letters. 570(1-3): 223-226.
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