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Arene ruthenium dithiolato-carborane complexes for boron neutron capture theory (BNCT)
Romero-Canelón, I. Phoenix, B. Pitto-Barry, Anaïs Tran, J. Soldevila-Barreda, Joan J. Kirby, N. Green, S. Sadler, P.J. Barry, Nicolas P.E.
Romero-Canelón, I.
Phoenix, B.
Pitto-Barry, Anaïs
Tran, J.
Soldevila-Barreda, Joan J.
Kirby, N.
Green, S.
Sadler, P.J.
Barry, Nicolas P.E.
Publication Date
2015
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© 2015 The Authors. Published by Elsevier B.V. This is an open access
article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ ).
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openAccess
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2015-05-08
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Abstract
We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a
highly hydrophobic organometallic arene ruthenium dithiolatoecarborane complex [Ru(p-cymene) (1,2-
dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer
P123 coreeshell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation,
towards human ovarian cancer cells (A2780; IC50 0.14 mM and 0.17 mM, respectively) and cisplatinresistant
human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 mM, respectively). Complex 1 was
particularly sensitive to neutron irradiation in A2780cisR cells (2.6 more potent after irradiation
compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles
resulted in higher cellular accumulation (2.5 ), and was sensitive to neutron irradiation in A2780 cells
(1.4 more potent upon irradiation compared to non-irradiation).
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Citation
Romero-Canelón I, Phoenix B, Pitto-Barry A et al (2015) Arene ruthenium dithiolato-carborane
complexes for boron neutron capture theory (BNCT). Journal of Organometallic
Chemistry. 796: 17-25.
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Article