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Part-time versus full-time occlusion therapy for treatment of amblyopia: A meta-analysis
Yazdani, N. Sadeghi, R. Momeni-Moghaddam, H. Zarifmahmoudi, L. Ehsaei, Asieh Barrett, Brendan T.
Yazdani, N.
Sadeghi, R.
Momeni-Moghaddam, H.
Zarifmahmoudi, L.
Ehsaei, Asieh
Barrett, Brendan T.
Publication Date
2017
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(c) 2017 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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Yes
Open Access status
openAccess
Accepted for publication
29/01/2017
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Abstract
Purpose: To compare full-time occlusion (FTO) and part-time occlusion (PTO) therapy in the treatment of amblyopia, with the secondary aim of
evaluating the minimum number of hours of part-time patching required for maximal effect from occlusion.
Methods: A literature search was performed in PubMed, Scopus, Science Direct, Ovid, Web of Science and Cochrane library. Methodological
quality of the literature was evaluated according to the Oxford Center for Evidence Based Medicine and modified Newcastle-Ottawa scale.
Statistical analyses were performed using Comprehensive Meta-Analysis (version 2, Biostat Inc., USA).
Results: The present meta-analysis included six studies (three randomized controlled trials [RCTs] and three non-RCTs). Pooled standardized
difference in the mean changes in the visual acuity was 0.337 [lower and upper limits: 0.009, 0.683] higher in the FTO as compared to the PTO
group; however, this difference was not statistically significant (P ¼ 0.056, Cochrane Q value ¼ 20.4 (P ¼ 0.001), I2 ¼ 75.49%). Egger's
regression intercept was 5.46 (P ¼ 0.04). The pooled standardized difference in means of visual acuity changes was 1.097 [lower and upper
limits: 0.68, 1.513] higher in the FTO arm (P < 0.001), and 0.7 [lower and upper limits: 0.315, 1.085] higher in the PTO arm (P < 0.001)
compared to PTO less than two hours.
Conclusions: This meta-analysis shows no statistically significant difference between PTO and FTO in treatment of amblyopia. However, our
results suggest that the minimum effective PTO duration, to observe maximal improvement in visual acuity is six hours per day.
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Published version
Citation
Yazdani N, Sadeghi R, Momeni-Moghaddam H et al (2017) Part-time versus full-time occlusion therapy for treatment of amblyopia: A meta-analysis. Journal of Current Ophthalmology. 29(2): 76-84.
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Article