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Poly(n-butyl Methacrylate) with Primary Amine End Groups for Supporting Cell Adhesion and Proliferation of Renal Epithelial Cells
Cox-Nowak, K. Al-Yamani, Ohood Grant, Colin A. Green, N.H. Rimmer, Stephen
Cox-Nowak, K.
Al-Yamani, Ohood
Grant, Colin A.
Green, N.H.
Rimmer, Stephen
Publication Date
2017
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(c) 2017 Taylor and Francis. This is an author's original manuscript of an article published by Taylor and Francis in the International Journal of Polymeric Materials and Polymeric Biomaterials in 2017.
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openAccess
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2017-02-08
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Abstract
Polymer coatings that support epithelial cell culture have been developed. Ozonolysis and subsequent work up of poly(butyl methacrylate-co-butadiene) copolymers is used to form oligomers with carboxylic acid end groups, which are then further reacted with diamines to provide poly(butyl methacrylate)s with primary amine end groups. The polymers are cast as films and used as cell culture substrates for human dermal fibroblasts and human renal epithelial cells. Fibroblast and epithelial cells adhere and proliferate on acid functional materials but on amine functional films epithelial cells show greater viability than fibroblasts.
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Accepted manuscript
Citation
Cox-Nowak K, Al-Yamani O, Grant CA et al (2017) Poly(n-butyl Methacrylate) with
Primary Amine End Groups for Supporting Cell Adhesion and Proliferation of Renal Epithelial
Cells. International Journal of Polymeric Materials and Polymeric Biomaterials. 66(15): 762-767.
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Article