Loading...
Cytotoxic hydrogen bridged ruthenium quinaldamide complexes showing induced cancer cell death by apoptosis
Lord, Rianne M. Allison, Simon J. Rafferty, K. Ghandhi, L. Pask, C.M. McGowan, P.C.
Lord, Rianne M.
Allison, Simon J.
Rafferty, K.
Ghandhi, L.
Pask, C.M.
McGowan, P.C.
Publication Date
2016-09-07
End of Embargo
Supervisor
Rights
© 2016 RSC. Reproduced with permission from the publisher in accordance with the publisher's self-archiving policy.
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2016-07-01
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
This report presents the first known p-cymene ruthenium quinaldamide complexes which are stabilised
by a hydrogen-bridging atom, [{(p-cym)RuIIX(N,N)}{H+}{(N,N)XRuII(p-cym)}][PF6] (N,N = functionalised
quinaldamide and X = Cl or Br). These complexes are formed by a reaction of [p-cymRu(μ-X)2]2 with a
functionalised quinaldamide ligand. When filtered over NH4PF6, and under aerobic conditions the equilibrium
of NH4PF6 ⇔ NH3 + HPF6 enables incorporation of HPF6 and the stabilisation of two monomeric
ruthenium complexes by a bridging H+, which are counter-balanced by a PF6 counterion. X-ray crystallographic
analysis is presented for six new structures with O⋯O distances of 2.420(4)–2.448(15) Å, which is
significant for strong hydrogen bonds. Chemosensitivity studies against HCT116, A2780 and cisplatinresistant
A2780cis human cancer cells showed the ruthenium complexes with a bromide ancillary ligand
to be more potent than those with a chloride ligand. The 4’-fluoro compounds show a reduction in
potency for both chloride and bromide complexes against all cell lines, but an increase in selectivity
towards cancer cells compared to non-cancer ARPE-19 cells, with a selectivity index >1. Mechanistic
studies showed a clear correlation between IC50 values and induction of cell death by apoptosis
Version
Accepted manuscript
Citation
Lord RM, Allison SJ, Rafferty K, Ghandi L, Pask CM and McGowan PC (2016) Cytotoxic hydrogen bridged ruthenium quinaldamide complexes showing induced cancer cell death by apoptosis. Dalton Transactions. 45: 13196-13203.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article