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Genotoxic Effects in Peripheral Blood and Sperm in Humans in Healthy Individuals and Those with Disease States
Anderson, Diana Baumgartner, Adolf Najafzadeh, Mojgan
Anderson, Diana
Baumgartner, Adolf
Najafzadeh, Mojgan
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2018-05-01
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Abstract
The Comet assay is one of the most versatile tools in toxicology today and can be used to
measure responses in both diploid (peripheral blood lymphocytes) and haploid (sperm)
primary cells in humans. This chapter will discuss how these cells are employed to
determine if they have differential responses to chemical and physical agents in healthy and
disease-affected individuals and how such information can be of use to man.
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Anderson D, Baumgartner A and Najafzadeh M (2018) Genotoxic Effects in Peripheral Blood and Sperm in Humans in Healthy Individuals and Those with Disease States. In: Anderson D, Waters MD and Marrs TC (Eds) The Comet Assay in Toxicology. Issues in Toxicology Series. No 30. 2nd Ed. Cambridge, UK: Royal Society of Chemistry. 457-476.
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