Loading...
Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension
Sharmin, Nahid Nganwuchu, Chinyere C. Nasim, Md. Talat
Sharmin, Nahid
Nganwuchu, Chinyere C.
Nasim, Md. Talat
Publication Date
2021-07
End of Embargo
Supervisor
Rights
© 2021 Elsevier Ltd. All rights reserved. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2021-04-07
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and clinical symptoms. This forum highlights the association of the TGF-β pathway with pathogenesis and therapeutic approaches.
Version
Accepted manuscript
Citation
Sharmin N, Nganwuchu CC and Nasim Md T (2021) Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension. Trends in Pharmacological Sciences. 42(7): 510-513.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article