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Development Of Novel Deep Eutectic Solvents For Optimization And Characterization, Involving Bio Extraction And Delivery Of Drugs With Poor Solubility

Magam, Harika R.
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Publication Date
End of Embargo
Supervisor
Kantamneni, Sriharsha
Kelly, Adrian
Keywords
Deep eutectic solvents (DES), Bio-extracts, Drug solubility, Design of experiment, Phytoconstituents, Development, Analytical characterisation, Stability study, Dissolution, Permeability
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Creative Commons License
The University of Bradford theses are licenced under a Creative Commons Licence.
Peer-Reviewed
Open Access status
Accepted for publication
Institution
University of Bradford
Department
School of Pharmacy. Faculty of Life Sciences
Awarded
2023
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PhD Thesis
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Additional title
Development of choline chloride and menthol based deep eutectic solvents (DES)
Abstract
DES are a specific category of liquid mixtures formed due to Vander Wal or hydrogen bond interactions between HBDs and HBAs, whose components usually remain as solids individually. DES are easy to prepare, biodegradable, cost effective and non- toxic. In this study we have synthesized different types of DES and explored their physical appearance and bond-structural characteristics, thermal characterization using DSC confirmed the formation of DES. The major goals of this thesis are to evaluate the potential of DES-based extraction for practical applications and enhance the solubility of poorly aqueous soluble drugs due to their lipophilic nature, considering this property of DES, solubility of several poorly soluble drugs was performed and quercetin, clofazimine had shown increased solubility in these solvents. DES solvents as extractant had shown increased extraction efficiency and had bypassed the limitations of organic extracts to be applied in cosmetic and pharmaceutical industry as they are safe to use, nonvolatile and stable. Overall, by characterizing the DES using thermal and spectral properties provided insights into the possible applications of these solvents as bio extracts characterization and solubilization vehicles of poorly soluble drugs. The bio extracts were qualitatively analysed for phytoconstituents extracted using liquid chromatography and the drug release profile of drug solubilize DES system was assessed using dissolution and permeability studies.
URI
https://bradscholars.brad.ac.uk/handle/10454/20877
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Type
Thesis
Qualification name
PhD
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