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Process simulation of twin-screw granulator: The effect of screw configuration on size distribution
Arthur, Tony B. Sekyi, Nana
Arthur, Tony B.
Sekyi, Nana
Publication Date
2023-06
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© 2023 The Authors. This is an Open Access article distributed under the the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/)
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openAccess
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2023-02-10
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Abstract
The effect of screw configuration on granule size distribution (GSD) using gPROMS FormulatedProduct (gFP) software to perform optimization, estimation of complex processes, and analyses is evaluated. Twin-screw granulation modeling was used to investigate the contribution of screw configuration and liquid-to-solid (L/S) ratio on GSD. Lactose and Avicel were the granulating materials. Twelve different configurations were investigated under three feed rates as consistent with literature and at various L/S ratios. Results indicate that kneading elements promote the recovery of 100-1000 µm granules while reducing the production of oversized granules. Higher feed rates support the production of fines and agglomerates, while a low feed rate produces 100-1000 µm granules.
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Citation
Arthur TB, Sekyi NKG, Rahmanian N et al (2023) Process simulation of twin-screw granulator: The effect of screw configuration on size distribution. Chemical Engineering and Technology. 46(6): 1251-1259.
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