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Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands
Rodríguez-Bárzano, A. Lord, Rianne M. Basri, A.M. Phillips, Roger M. Blacker, A.J. McGowan, P.C.
Rodríguez-Bárzano, A.
Lord, Rianne M.
Basri, A.M.
Phillips, Roger M.
Blacker, A.J.
McGowan, P.C.
Publication Date
2015-02
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© 2015 RSC. Reproduced with permission from the publisher in accordance with the publisher's self-archiving policy.
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Yes
Open Access status
openAccess
Accepted for publication
2014-12-14
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Abstract
The complexes [RuCp*(PP)Cl] (Cp* = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp#(PP)Cl] (Cp# =
C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp*(dppm)(CH3CN)][SbF6] [3] were synthesized
and evaluated in vitro as anticancer agents. Compounds 1–3 gave nanomolar IC50 values against
normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their
high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.
Version
Accepted manuscript
Citation
Rodríguez-Bárzano A, Lord RM, Basri AM, Phillips RM, Blacker AJ and McGowan PC (2015) Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing
chelating diphosphine ligands. Dalton Transactions. 44: 3265-3270.
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Article