Publication

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

; ; ; ; 
Sheldrake, Helen M.
; 
Guino, M.
; 
Kiakos, K.
; 
Hartley, J.A.
; 
Searcey, M.
; 
Patterson, Laurence H.
Citations
Google Scholar:
Lookup
Altmetric:
Publication Date
2011
End of Embargo
Supervisor
Keywords
Alkylating agents, Animals, Biotransformation, CHO cells, Cricetinae, Cricetulus, Cytochrome P-450 CYP1A1, Cytotoxins, Humans, Indoles, Molecular targeted therapy, Oxidation-reduction, REF 2014
Rights
Peer-Reviewed
Yes
Open Access status
closedAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Collections
Life Sciences Publications
Show all metadata
Additional title
Abstract
The identification of an agent that is selectively activated by a cytochrome P450 (CYP) has the potential for tissue specific dose intensification as a means of significantly improving its therapeutic value. Towards this goal, we disclose evidence for the pathway of activation of a duocarmycin analogue, ICT2700, which targets CYP1A1 for biological activity.
URI
https://bradscholars.brad.ac.uk/handle/10454/6138.2
Version
No full-text in the repository
Citation
Pors K, Loadman PM, Shnyder SD et al (2011) Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity. Chemical Communications. 47(44): 12062-12064.
Link to publisher’s version
Link to published version
Link to Version of Record
https://doi.org/10.1039/c1cc15638a
Type
Article
Qualification name
Notes

Version History

Now showing 1 - 2 of 2
VersionDateSummary
2*
 2025-05-01 14:37:01
Editing author name
1
 2014-04-28 11:14:24
* Selected version