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The Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of Post-Receptoral Processing
Jacob, M.M. Pangeni, G. Gomes, B.D. Souza, G.S. Da Silva Filho, M. Silveira, L.C.L. Maguire, John Parry, Neil R.A. McKeefry, Declan J. Kremers, Jan
Jacob, M.M.
Pangeni, G.
Gomes, B.D.
Souza, G.S.
Da Silva Filho, M.
Silveira, L.C.L.
Maguire, John
Parry, Neil R.A.
McKeefry, Declan J.
Kremers, Jan
Publication Date
2015-03-18
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© 2015 The Authors. Published by PLOS. Reproduced in accordance
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Abstract
We studied the spatial arrangement of L- and M-cone driven electroretinograms (ERGs) reflecting
the activity of magno- and parvocellular pathways. L- and M-cone isolating sine
wave stimuli were created with a four primary LED stimulator using triple silent substitution
paradigms. Temporal frequencies were 8 and 12 Hz, to reflect cone opponent activity, and
30, 36 and 48 Hz to reflect luminance activity. The responses were measured for full-field
stimuli and for different circular and annular stimuli. The ERG data confirm the presence of
two different mechanisms at intermediate and high temporal frequencies. The responses
measured at high temporal frequencies strongly depended upon spatial stimulus configuration.
In the full-field conditions, the L-cone driven responses were substantially larger than
the full-field M-cone driven responses and also than the L-cone driven responses with
smaller stimuli. The M-cone driven responses at full-field and with 70° diameter stimuli displayed
similar amplitudes. The L- and M-cone driven responses measured at 8 and 12 Hz
were of similar amplitude and approximately in counter-phase. The amplitudes were constant
for most stimulus configurations. The results indicate that, when the ERG reflects luminance
activity, it is positively correlated with stimulus size. Beyond 35° retinal eccentricity,
the retina mainly contains L-cones. Small stimuli are sufficient to obtain maximal ERGs at
low temporal frequencies where the ERGs are also sensitive to cone-opponent processing
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Jacob MM, Pangeni G, Gomes BD, Souza GS, da Silva Filho M, Silveira LCL, et al. (2015) The Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of
Post-Receptoral Processing. PLoS ONE. 10(3): e0121218.
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