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Biomedical applications of MXene-integrated composites: regenerative medicine, infection therapy, cancer treatment, and biosensing
Maleki, A. Ghomi, M. Nikfarjam, N. Akbari, M. Sharifi, E. Shahbazi, M-A. Kermanian, M. Seyedhamzeh, M. Zare, E.N. Mehrali, M.
Maleki, A.
Ghomi, M.
Nikfarjam, N.
Akbari, M.
Sharifi, E.
Shahbazi, M-A.
Kermanian, M.
Seyedhamzeh, M.
Zare, E.N.
Mehrali, M.
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Publication Date
2022-08
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© 2022 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/)
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2022-05
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Abstract
MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have
emerged as a new subclass of 2D materials. Due to their outstanding physicochemical
and biological properties, MXenes have gained much attention
in the biomedical field in recent years, including drug delivery systems,
regenerative medicine, and biosensing. Additionally, the incorporation
of MXenes into hydrogels has garnered significant interest in biomedical
engineering as an electroactive and mechanical nanoreinforcer capable of
converting nonconductive scaffolds into excellent conductors of electricity
with an impressive effect on mechanical properties for the engineering of
electroactive organs and tissues such as cardiac, skeletal muscle, and nerve.
However, many questions and problems remain unresolved that need to be
answered to usher these 2D materials toward their true destiny. Thus, this
review paper aims to provide an overview of the design and applications of
MXene-integrated composites for biomedical applications, including cardiac
tissue engineering, wound healing, infection therapy, cancer therapy, and
biosensors. Moreover, the current challenges and limitations of utilizing
MXenes in vivo are highlighted and discussed, followed by its prospects
as a guideline toward possible various futuristic biomedical applications.
This review article will inspire researchers, who search for properties,
opportunities, and challenges of using this 2D nanomaterial in biomedical
applications.
MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have emerged as a new subclass of 2D materials. Due to their outstanding physicochemical and biological properties, MXenes have gained much attention in the biomedical field in recent years, including drug delivery systems, regenerative medicine, and biosensing. Additionally, the incorporation of MXenes into hydrogels has garnered significant interest in biomedical engineering as an electroactive and mechanical nanoreinforcer capable of converting nonconductive scaffolds into excellent conductors of electricity with an impressive effect on mechanical properties for the engineering of electroactive organs and tissues such as cardiac, skeletal muscle, and nerve. However, many questions and problems remain unresolved that need to be answered to usher these 2D materials toward their true destiny. Thus, this review paper aims to provide an overview of the design and applications of MXene-integrated composites for biomedical applications, including cardiac tissue engineering, wound healing, infection therapy, cancer therapy, and biosensors. Moreover, the current challenges and limitations of utilizing MXenes in vivo are highlighted and discussed, followed by its prospects as a guideline toward possible various futuristic biomedical applications. This review article will inspire researchers, who search for properties, opportunities, and challenges of using this 2D nanomaterial in biomedical applications.
MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have emerged as a new subclass of 2D materials. Due to their outstanding physicochemical and biological properties, MXenes have gained much attention in the biomedical field in recent years, including drug delivery systems, regenerative medicine, and biosensing. Additionally, the incorporation of MXenes into hydrogels has garnered significant interest in biomedical engineering as an electroactive and mechanical nanoreinforcer capable of converting nonconductive scaffolds into excellent conductors of electricity with an impressive effect on mechanical properties for the engineering of electroactive organs and tissues such as cardiac, skeletal muscle, and nerve. However, many questions and problems remain unresolved that need to be answered to usher these 2D materials toward their true destiny. Thus, this review paper aims to provide an overview of the design and applications of MXene-integrated composites for biomedical applications, including cardiac tissue engineering, wound healing, infection therapy, cancer therapy, and biosensors. Moreover, the current challenges and limitations of utilizing MXenes in vivo are highlighted and discussed, followed by its prospects as a guideline toward possible various futuristic biomedical applications. This review article will inspire researchers, who search for properties, opportunities, and challenges of using this 2D nanomaterial in biomedical applications.
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Maleki A, Ghomi M, Nikfarjam N et al (2022) Biomedical applications of MXene-integrated composites: regenerative medicine, infection therapy, cancer treatment, and biosensing. Advanced Functional Materials. 32(34): 2203430.
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