Thumbnail Image
Publication

The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis

Wall, M.J.
; 
CorrĂȘa, Sonia A.L.
Publication Date
2017
End of Embargo
Supervisor
Keywords
AMPA receptors, Arc/Arg3.1, Adaptor protein 2, Endocytosis, Rectification
Rights
(c) 2017 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
cb
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2017-09-06
Institution
Department
Awarded
Embargo end date
Collections
Life Sciences Publications
Show all metadata
Files
Keep suppressed - has older cover sheet pre-publish
Adobe PDF, 776.36 KB
Additional title
Abstract
The activity-regulated cytoskeleton associated protein (Arc/Arg3.1) plays a key role in determining synaptic strength through facilitation of AMPA receptor (AMPAR) endocytosis. Although there is considerable data on the mechanism by which Arc induction controls synaptic plasticity and learning behaviours, several key mechanistic questions remain. Here we review data on the link between Arc expression and the clathrin-mediated endocytic pathway which internalises AMPARs and discuss the significance of Arc binding to the clathrin adaptor protein 2 (AP-2) and to endophilin/dynamin. We consider which AMPAR subunits are selected for Arc-mediated internalisation, implications for synaptic function and consider Arc as a therapeutic target.
URI
http://hdl.handle.net/10454/13240
Version
Accepted manuscript
Citation
Wall MJ and Correa SAL (2017) The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis. Accepted for publication
Link to publisher’s version
Link to published version
Link to Version of Record
https://doi.org/10.1016/j.semcdb.2017.09.005
Type
Article
Qualification name
Notes