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Supramolecular chemistry enables vat photopolymerization 3D printing of novel water-soluble tablets
Ong, J.J. Chow, Y.L. Gaisford, S. Cook, M.T. Telford, Richard Rimmer, Stephen Qin, Y. Mai, Y. Goyanes, A.
Ong, J.J.
Chow, Y.L.
Gaisford, S.
Cook, M.T.
Telford, Richard
Rimmer, Stephen
Qin, Y.
Mai, Y.
Goyanes, A.
Publication Date
2023-08-25
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© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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2023-07-30
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Abstract
Vat photopolymerization has garnered interest from pharmaceutical researchers for the fabrication of personalised medicines, especially for drugs that require high precision dosing or are heat labile. However, the 3D printed structures created thus far have been insoluble, limiting printable dosage forms to sustained-release systems or drug-eluting medical devices which do not require dissolution of the printed matrix. Resins that produce water-soluble structures will enable more versatile drug release profiles and expand potential applications. To achieve this, instead of employing cross-linking chemistry to fabricate matrices, supramolecular chemistry may be used to impart dynamic interaction between polymer chains. In this study, water-soluble drug-loaded printlets (3D printed tablets) are fabricated via digital light processing (DLP) 3DP for the first time. Six formulations with varying ratios of an electrolyte acrylate …
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Citation
Ong JJ, Chow YL, Gaisford S et al (2023) Supramolecular chemistry enables vat photopolymerization 3D printing of novel water-soluble tablets. International Journal of Pharmaceutics. 643: 123286.
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Article